Yay or Neigh: What’s the Deal with Ivermectin?

It would be the ultimate dinner party argument starter… that is, if we were still allowed to have dinner parties. Ivermectin. It’s either a miracle drug or a horse dewormer – the opinion varies depending on who you talk to. 

Popular podcaster, Joe Rogan accidentally stoked the debate when he casually mentioned that he ‘threw the kitchen sink’ at his virus symptoms – using monoclonal antibodies, NAD, a Vitamin D drip and ivermectin to beat COVID-19 in just three days.

The internet exploded. 

CNN reported that he took horse dewormer, perhaps following on from the FDA’s condescending tweet (‘You are not a horse. You are not a cow. Seriously, y’all. Stop it.’) about the drug a few weeks ago. Rolling Stone promptly stepped in a steaming pile of its own creation by claiming a plague of ivermectin overdoses at a rural hospital in Oklahoma, which turned out to be a fabrication. MSNBC news host, Rachel Maddow, failed to verify the story before diving headlong in the mess. A report was made attempting to link ivermectin to male infertility, but it backfired when the FDA issued a public statement that this was not a known side-effect. Even the Associated Press had to backpedal, after falsely claiming that ivermectin was responsible for 70% of the poisoning cases reported to Mississippi Poison Control – it turns out the correct figure was only 2%. 

Nevertheless, the shit storm continued, with our own TGA coming out with new restrictions for the prescription of oral ivermectin. They cautioned that GPs are now only able to prescribe it for already approved conditions, such as scabies and parasitic infections. Apparently, it turns out there was an unexpected increase in consumer demand that led to drug shortages. 

So, what is it about the medicine that is so polarising? 

For a drug that has been used in humans for 40 years, that’s on the WHO’s list of essential medicines, with ‘almost no side effects’ and with a solid safety profile making overdose very difficult (‘doses up to 10 times the approved limit are well tolerated by healthy volunteers’); the media’s treatment of ivermectin has been nothing short of extraordinary. 

Funnily enough, until COVID-19 came along, scientists couldn’t sing enthusiastically enough about the wonders of the Nobel-prize winning formulation. It was a ‘versatile drug with unique characteristics’, an ‘enigmatic multifaceted wonder drug’ that was ‘continuing to surprise and excite scientists’ due to its ‘unexpected potential as an antibacterial, antiviral and anti-cancer agent’. Drug company, Merck, benevolently bestowed millions of doses on impoverished patients in West Africa to treat river blindness. 

The first suggestion that ivermectin may be useful in treating COVID-19 came from within our own shores, with a lab discovery at Monash University, Clayton. Evidence of success on the ground began to roll in from all around the world. A study in Argentina found that zero patients who used a combined ivermectin and IotaCarrageenan program became infected with COVID-19. This is remarkable on its own, but even more so when compared with the PPE group, which reported an ‘overall infection rate of 58.2%’ (237 out of 407 people). Since then there have been many more reports by frontline doctors with favourable results, which includes comparisons between the vaccine and ivermectin roll out in Peru, findings of a 73% reduction of SARS-CoV-2 infection among healthcare workers in India, and a trial of health care workers who took ivermectin chemoprophylaxis. These workers had an 83% lower risk of contracting COVID-19 in the following month

Closer to home, Australian Professor Thomas Borody developed a ground-breaking ‘Triple Therapy Protocol’ in August 2020, to enable treatment of the vulnerable elderly and frontline workers. Emeritus Professor Robert Clancy, a Senior Clinical Immunologist of the University of Newcastle has also backed the drug, telling Paul Turton on ABC Drive (in a now mysteriously scrubbed interview) that the science was ‘crystal clear’. Recently, Dr Phillip Altman (Honours in Pharmacy, Master of Science and a Doctor of Philosophy (in both pharmacology and pharmaceutical chemistry) wrote an open letter to the head of the National COVID Clinical Evidence Taskforce, begging him to demand ‘revised recommendations for the use of ivermectin within 14 days’.

Ivermectin is effective when used as prophylaxis (to stop you from catching COVID-19), as an early treatment in order to reduce symptoms and to reduce the severity of the disease. An American Journal of Therapeutics peer-reviewed meta-analysis reported ‘moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using Ivermectin’ – a finding that has stood strong, despite a number of attempts to discredit it (including the error-riddled Roman et al paper and the Cochrane review). One could easily spend days reading the multitude of papers now available in support of the use of ivermectin.

So why are we not, as they say, ‘following the science’? 

Some are demanding even more robust evidence (despite the fact that they gloss over any such requirements for vaccine trials), pinning their hopes on the Oxford University PRINCIPLE trial, the design of which has already raised a few concerns in scientific circles

The fact is, we already have more than enough data to be able to roll out this cheap, safe and effective drug. If the aim is to reduce deaths from COVID-19, any curtailing of this treatment is unsupportable. Governmental and regulatory resistance is, at best, puzzling, and, at worst, potentially criminally negligent – in that the lives of so many are at stake here. 

We don’t even care what you want to call it. Just let us have the damn horse medicine!

References: 

Background 

Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19

Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

WHO Model List of Essential Medicines

Safety 

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

Ivermectin 1% Cream (Soolantra) for Inflammatory Lesions of Rosacea

Effect of Ivermectin on Anopheles gambiae Mosquitoes Fed on Humans: The Potential of Oral Insecticides in Malaria Control

Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques

Lab Studies and Clinical Trials

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action

Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

Study of the Efficacy and Safety of Topical Ivermectin + IotaCarrageenan in the Prophylaxis against COVID-19 in Health Personnel 

Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments

Ivermectin as Pre-exposure Prophylaxis for COVID-19 among Healthcare Providers in a Selected Tertiary Hospital in Dhaka – An Observational Study

Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial

Efficacy (opinion and meta-analysis)

‘It’s crystal clear’: Professor Robert Clancy backs ivermectin as a COVID-19 treatment

A Sad and Shameful Day for Australian Medicine (Emeritus Professor Robert Clancy, Quadrant)

‘A Total Lack of Therapeutic Perspective’ (Dr Phillip Altman, Quadrant)

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

Concerns and responses

Bayesian hypothesis testing and hierarchical modelling of ivermectin effectiveness in treating Covid-19

Statement of Concern and Request for Retraction Re: Roman Y M, Burela P A, Paspuleti V, Piscoya A, Vidal J E and Hernandez A V (Bryant et al)

Efficacy of ivermectin in Covid-19 (Bryant et al response to Cochrane review – Popp et al)

What the Media Isn’t Telling You About the University of Oxford’s Study on Ivermectin

News links

Joe Rogan Instagram post

Australian GPs banned from prescribing Ivermectin to Covid-19 patients

STROMECTOL ivermectin 3mg tablet blister pack – medicine shortage information

Press Release: Ivermectin Triple Therapy Protocol for COVID-19 released to Australian GPs as treatment for Infected Elderly, Frontline Workers

More information

Evidence regarding ivermectin: A collation of studies

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Responses

  1. Yes, lets get this addressed – then all our problems are solved:
    1) no need for lockdowns
    2) everyone back at work
    3) hospitals empty of COVID patients
    4) emergency powers revoked

    Then we need to:
    1) Arrest and prosecute the people behind the TGA decision to ban ivermectin. Also all the health authorities that ignored the science on this. It might pay to investigate their links with Big Pharma.
    2) ‘re-train’ all the police who abused people’s rights during the lockdowns
    3) Replace most of our politicians at the next election
    4) Return to our Christian roots and roll back the evil laws that a) ban praying for, or trying to help, troubled trans people, b) criminalise people distributing anti-abortion materials, and many other abominable laws passed in recent years.

    1. Yes Matthew, well said. But how do we get this underway when the ‘system’, which is the State Governments, the bureaucrats and the media appear to have so much power and influence over the general run of sheeple?

      1. They are digging their own graves as they become more desperate trying to hold to their quickly disintegrating narrative – you can see it in the police who are becoming more and more anxious and irrationally aggressive. This will wake a lot of people up. But this had to happen, we stood by and allowed our elites and leaders to lead us down a Godless path – these troubles have a silver lining in that people now see the outcome of having such Godless people in charge.